Vitamin A–Not for Your Eyes Only: Requirement for Heart Formation Begins Early in Embryogenesis
نویسنده
چکیده
Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the experimental models used, the vitamin A-deficient avian embryo has been an important tool to study the function of vitamin A during early heart formation. A cluster of retinoic acid-regulated developmental genes have been identified that participate in building the heart. In the absence of retinoic acid the embryonic heart develops abnormally leading to embryolethality.
منابع مشابه
Vitamin a requirement for early cardiovascular morphogenesis specification in the vertebrate embryo: insights from the avian embryo.
Vitamin A is required throughout the life cycle, including crucial stages of embryonic and fetal development. With the identification of retinoic acid-specific nuclear transcription factors, the retinoid receptors, considerable advances have been made in understanding the molecular function of vitamin A. The requirement for vitamin A during early embryogenesis has successfully been examined in ...
متن کاملImpact of hypokinesia on dynamics of formation of evoked potentials in sensorimotor cortex in early postnatal ontogenesis
The analysis of evoked potentials of sensorimotor cortex in response to electrical stimulation of n. ischiadicus shows that the extremal factor hypokinesia has a negative impact on the dynamics of formation of amplitudal and temporal characteristics since eyes openning in 2-weeks old rats. The most vulnerable process to the impact of hypokinesia is the first-positive phase, which disappears in ...
متن کاملImpact of hypokinesia on dynamics of formation of evoked potentials in sensorimotor cortex in early postnatal ontogenesis
The analysis of evoked potentials of sensorimotor cortex in response to electrical stimulation of n. ischiadicus shows that the extremal factor hypokinesia has a negative impact on the dynamics of formation of amplitudal and temporal characteristics since eyes openning in 2-weeks old rats. The most vulnerable process to the impact of hypokinesia is the first-positive phase, which disappears in ...
متن کاملP-24: Opioid and Progesterone Signaling Is Obligatoryfor Early Human Embryogenesis
Background: The growth factors that drive the division and differentiation of stem cells during early human embryogenesis are unknown. The secretion of endorphins, progesterone (P(4)), human chorionic gonadotropin, 17beta-estradiol, and gonadotropin-releasing hormone by trophoblasts that lie adjacent to the embryoblast in the blastocyst suggests that these pregnancy-associated factors may direc...
متن کاملA Study on Evening-Primrose (Oenothera biennis L.) Callus Regeneration and Somatic Embryogenesis
Evening primrose (Oenothera biennis L.) is a wild flower with high and valuable oil content. High seedshattering, indeterminate inflorescence and heterogeneous germination limit the commercial cultivation ofthis plant. Besides agronomical research, breeding programs can also remedy the above mentioned problems.Since traditional breeding methods take a long time, using techniqu...
متن کامل